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a neuroscientific basis for using benzos in panic disorder ?

Question:
Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder.






Answer:
I've *never* heard of anybody having any success with Gabitril. Of course I haven't read the study itself but I'm far from convinced.

why is the general opinion of most psychiatrists in favor of ssri's over benzo's for anxiety and panic? what is their problem with benzo's?

They usually site 3 reasons:

1) benzos can cause dependence (but so can antidepressants)

2) benzos can cause a withdrawal syndrome when stopped (so can antidepressants)

3) benzos are "addictive" (studies have shown that benzo abuse is rare in people with anxiety disorders)

And another factor is that psychiatry professors who teach residents and write the psychiatric textbooks are very often paid consultants by the manufacturers of antidepressants. I am uncertain to what extent this biases them against benzos and for antidepressants.

SSRI's are hyped up big time while benzos are (wrongly) felt to be *addictive*. They should do their homework.

It likely has to do with profit margins, but that's just a guess on my part. I would be interested to know what kind of profit percentage drug companies make on, for instance, generic clonazepam, and compare it to that of name-brand Wellbutrin or Prozac. I wonder if that information is available to the general public.

I'll second that! I've been using alprazolam (Xanax) for about a decade now and have yet to experience adverse side effects nor increased dependence (works as well now as it did when I started). My dosage is purely PRN (some days I use none at all, up to 3 or rarely 4-mg during very bad days, on average about 1.5-mg per day).

I've been taking .75 mgs per day of Xanax for about 3 weeks now, after a SEVERE panic attack (combined w/ hyperventilation) which sent me to the ER (it was my first attack I thought I was having a heart attack, despite the fact that I'm only 35 yrs old.)

I love it - I can't believe how much it has helped me!

I only hope that my doctor keeps prescribing it for me, as I think it is working very well and don't need see any need to switch.





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